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KMID : 0379520010170010011
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한국독성학회지
2001 Volume.17 No. 1 p.11 ~ p.15
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The Effect of Repeated Application of A Mouthwash to the Mucosa of the Hamster Cheek Pouch
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Kang Kyung-Sun
Che Jeong-Hwan
Kim Hyung-Sub
Kim Kyung-Bae
Lee Ji-Hae
Cho Sung-Dae
Cho Jong-Ho
Kim Bae-Hwan
Lee Byung-Ryeul
Lee Yong-Soon
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Abstract
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This study was carried out to evaluate the irritant potential of A mouthwash in hamster cheek pouch. The test substances were applied twice daily to right pouches of hamsters for 14 consecutive days. Animals were administered with A mouthwash, Listerine, saline and control solution, respectively. In order to evaluate the irritant potential in mucosa of hamster cheek pouch, we observed clinical signs, mortality, body weight changes and gross and histopathological findings for 14 days. In all groups, there were neither dead animals nor significant changes of body weights. In addition, there were no differences between saline and A mouthwash treated group in gross and histopathological findings. Therefore, these results suggest that there was no irritant potential of A mouthwash in hamster cheek pouch
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KEYWORD
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Irritant potential, A mouthwash, Hamster cheek pouch
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